ThisHighSensitivityELISAenablestheanalysisofInterleukin-10inlowconcentrationsfromserum,plasma,orcellculturesamples.TheHighSensitivityELISAKitsofferaccuratequantificationbelowconventionalELISAlimits.Thisismadeposs
IBLebytheirinherentdesignbyamplifyingthesignal.
Interleukin-10isapleiotropiccytokineplayinganimportantroleasaregulatoroflymphoidandmyeloidcellfunction.InhumansIL-10isproducedbyactivatedCD8(+)peripheralbloodT-cells,byT-helperCD4(+)T-cellclones.Duetothe
ABIlityofIL-10toblockcytokinesynthesisandseveralaccessorycellfunctionsofmacrophagesthiscytokineisapotentsuppressoroftheeffectorfunctionsofmacrophages,T-cellsandNKcells.Inaddition,IL-10participatesinregulatingproliferationanddifferentiationofB-cells,mastcellsandthymocytes.Basedonitsprimarystructure,IL-10isamemberofthefoura-helixbundlefamilyofcytokines.InsolutionhumanIL-10isahomodimerwithanapparentmolecularmassof39kDa.AlthoughitcontainsanN-linked,glycosylationsite,itlacksdetectablecarbohydrates.RecombinantproteinexpressedinE.colithusretainsallknown
BIOLOGicalactivities.ThehumanIL-10geneislocatedonchromosome1andispresentasasinglecopyinthegenome.ThehumanIL-10exhibitsstrongDNAandaminoacidsequencehomologytothemurineIL-10andanopenre
ADIngframeintheEpstein-Barrvirusgenome,BCRF1whichsharesmanyofthecellularcytokine"sbiologicalactivitiesandmaythereforeplayaroleinthehost-virusinteraction.TheimmunosuppressivepropertiesofIL-10suggestapossibleclinicaluseofIL-10insuppressingrejectionsofgraftsafterorgantransplantations.IL-10canfur
Thermoreexertstronganti-inflammatoryactivities.
Synonyms:Cytokinesynthesisinhibitoryfactor,CSIF
ForconcretedatapleaseconsulttheInstructionforUseinthedownloadboxontherightside.