Immunoenzymetricassayforthequantitativemeasurementof25-hydroxyvitaminD2andD3(25OH-D2and25OH-D3)inratserum.
VitaminDisthegenerictermusedtodesignateVitaminD2orergocalciferolandVitaminD3orcholecalciferol.
Inthelivermainly,VitaminD3ismetabolisedinto25-HydroxyvitaminD3(25OHD3)whichisthemainformofVitaminDcirculatinginthebody.
25OHD3isaprecursorforotherVitaminDmetabolitesandhasalsoalimitedactivitybyitself.
Themostactivederivativeis1,25-hydroxyvitaminD3,producedinthekidney(orplacenta)by1-hydroxylationof25OHD3.
25OHVitaminDstimulatestheintestinalabsorptionofbothcalciumandphosphorusandalsoboneresorptionandmineralisation.Ratshavebeenusedasexperimentalmodeltoinvestigatetheeffectof25OHVitaminDsupplementsonfracturehealing.
25OHVitaminDmightalsobeactiveinothertissuesrespons
IBLeforcalciumtransport(placenta,kidney,mammarygland…)andendocrinegland(parathyroidglands,betacells…).
VitaminD3andVitaminD2arealsoavailablebyingestionthroughfoodordietarysupplementation.
AsVitaminD2ismetabolisedinasimilarwaytoVitaminD3,bothcontributetotheoverallVitaminDstatusofanindividual.
StudiesonratshavebeenconductedtocomparemetabolismoforalVitaminD2andoralVitaminD3.(6)andtodefinetheeffectofVitaminD3intakeoncalciummetabolism.
InfluenceofvitaminDdeficiencyduringintrauterineandearlylifeonbloodpressurehasbeensuitedinaratmodel.InstudiesonratPTH(parathyroidhormone),25OHvitaminDismeasuredinratserumtodetermineitsinfluenceonPTHsecretion.
ForconcretedatapleaseconsulttheInstructionforUseinthedownloadboxontherightside.