| Kitsize | 12x8 |
| Method | ELISA |
| Incubationtime | 1x60min,1x30min |
| Standardrange | 0.15-20ng/mL |
| Specimen/Volumes | 25µLserum,plasma |
| Substrate/isotope | TMB450nm |
| RegulatoryStatus: | EU:CE,CDN:IVD |
17-OH-progesterone(17-OHP)isthemostsuitablebiochemicalMarkerforthediagnosisofcongenitaladrenalhyperplasia(CAH).CAHhasaprevalenceof1-20in10,000childrenanditisoneofthemostfrequentinbornendocrinedisorders.
ThemostcommonformofCAHisduetoadeficiencyoftheenzyme21-hydroxylase.Dependingontheseverityoftheenzymaticdefect,theCAHrelatedsymptomsvaryfromsaltlostsyndromeininfantstohirsutismand/orinfertilitythatmanifestduringpubertyoradulthood(late-onsetCAH).
AdvantagesoftheIBLInternational17-OHPELISA
- Excellentanalyticalcharacteristics
- Forthe17-OHPserumELISAage-dependentreferencerangesforchildren
- Easy17-OHPmonitoringinsaliva
- Serum,plasmaELISA:EU:CE
- Easytoadapttoautomatedinstruments
Measuring17-OHPenablesearlydiagnosisandtreatmentofpatientssufferingfromCAH.
Femalepatientswithlate-onsetCAHusuallyhave17-OHPconcentrationsabovethereferenceintervalduringthefollicularphaseofthemenstrualcycle.
17-OHPissecretedinabundantexcessinaffectedinfantswith21-hydroxylasedeficiencywhencomparedtohealthychildren.Normalserum17-OHPvaluesininfantsandchildrenareshownbelow.
Normal17-OHPserumvaluesforinfantsandchildren
17-OH-Progesteronein195seraofinfants
17-OH-Progesteronein139seraofchildren
Thisproductrepresentstherightalternativetothesoondiscontinued17-aOH-ProgesteroneCACRIAfromSiemens.Pleasecontactusifyoushouldneedanykitfortrialpurposes!Orifyoushouldneedanysupportregardingcomparisonstudies.Wewillbehappytoprovideyouwithexpectedhelp.
ExcellentreplacementforRIA
AvalidationstudybytheAustralianlaboratoryACTshowsthatIBL’s17-OH-ProgesteroneELISAprovidesanexcellentalternativefortheSiemensHealthcareDiagnostics(formerlyDPC)17-aOH-ProgesteroneRIA.Thedatacanviewedhere:
EscapefromRIA-ACTPoster2013
Pleasecontactusifyouwouldbeinterestedtoperformyourowninternalvalidationstudy.
HighcorrelationtoGC-MS/MSshowninExternalQualityAssessmentScheme
ThelatestsurveystudybytheReferenceforBioanalyticsinBonn,Germany,againconfirmedthecorrectcalibrationandreliABIlityofourassay.
RfBsurveyresults
ExcerptfromtheInstructionsforUse
Enzymeimmunoassayforthein-vitro-diagnosticquantitativedeterminationof17-OH-Progesteroneinhumanserumandplasma.17-OH-progesterone(17-OHP)isthemostsuitablebiochemicalmarkerforthediagnosisofCongenitalAdrenalHyperplasia(CAH).CAHhasaprevalenceofaround1-20in10,000childrenandisoneofthemostfrequentinbornendocrinedisorders.Thespectrumofclinicalpresentationsrangesfromformswithneonatalsymptoms,i.e.saltwastingandsimplevirilizingforms,tonon-classicalformsthatmightnotmanifestuntiladulthood.MeasuringthissteroidenablesearlydiagnosisandtreatmentinpatientssufferingfromCAH.17-OHPissecretedinabundantexcessinaffectedinfantsdueto21-hydroxylasedeficiency.Femalepatientswithlate-onsetCAHusuallyhave17-OHPconcentrationsabovethereferenceintervalforthefollicularphaseofthemenstrualcycle.
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