IBL/soluble α-Klotho ELISA/JP27998/,IBL,,IBL,TECAN,IBL International,ibl-international,+,,Array.Array.Array蚂蚁淘厂家直采.

产品名称：IBL/soluble α-Klotho ELISA/JP27998/

产品编号：JP27998

市场价：¥0.00

场地：美国(厂家直采)

产品分类：试剂盒>ELISA试剂盒>夹心法ELISA>

联系QQ：1570468124

电话号码：4000-520-616

邮箱： info@ebiomall.com

美元价：待定

品牌： IBL

公司：IBL,inc

公司分类：

商品介绍

Kitsize	12x8
Method	ELISA
Incubationtime	1x1h,2x30min
Standardrange	93.75-2000pg/mL
Specimen/Volumes	100µlserum,EDTA-plasma
Substrate/isotope	TMB450nm
RegulatoryStatus:	Forresearchuseonly

Detailsfor: solubleα-KlothoELISA

Anovelmessengerofhealthybodies?!

α-Klotho,namedaftertheGreekGoddessofFate,Clotho,whospinsthethreadoflife,wasoriginallycharacterizedasanagingsuppressorgene.OurELISAisperfectlysuitedforthemeasurementoftheproductofthisgene-theα-Klothoprotein.α-Klothoisalsoknownasthemessengerofhealthybodies(FantuzziGFrontImmunol.2014Jul21;5:351).

Adefectinklothogeneexpressioninthemouseresultsinasyndromethatresembleshumanageing,includingashortLifespan,infertility,arteriosclerosis,skinatrophy,osteoporosisandemphysema.Theabsenceofα-Klotholeadstoasubstantiallylowerbonedensitythanusual(Kuro-oMetal.Nature.1997Nov6;390(6655):45-51).

alpha-Klotho deficiency leads to bone mass density loss — Picture:α-Klothodeficiencyleadstobonemassdensitylossasthecomparisonofwildtype(left)andα-Klothoknockoutmice(right)demonstrates(picturekindlyprovidedbyDr.YoichiNabeshima,LaboratoryofMolecularScience,InstituteofBiomedicalResearchandInnovation,FoundationforBiomedicalResearchandInnovation,Kobe,Japan)

Sincethediscoveryofα-Klotho,whichwasdescribedinthepublicationmentionedabove,severalresearchareashaveemergedwhichbenefitfromthedeterminationofα-Klothointermsofgainingvaluableadditionalinformation:

Bonemetabolism
Agingprocesses
Nephrology
Immunology,etc.

α-KlothoandFGF23arethemainmediatorsofcalciumandphosphatehomeostasis.Anykindofdisturbanceinthisregard,suchasareducedorincreasedproductionofα-Klotho,leadstometabolicbonedisorders(JohnGBetal.AmJKidneyDis.2011Jul;58(1):127-34).

Itisalreadyknownthatα-Klotholevelsinblooddecreasewithage(YamazakiYetal.BiochemBiophysResCommun.2010Jul30;398(3):513-8).Lowα-klotholevelsareoftenassociatedwithage-relateddiseases.

Theoutcomesofresearchintheareasofbonemetabolismandaging,aswellasthefactthatα-Klothoisproducedexclusivelyinthekidneysandbrain,havepromptedinvestigationsintotheimpactofchangesinα-Klotholevelsinrenaldisease.Studieshaverevealedthatα-klotholevelsaresignificantlydecreasedintheserumalreadyatanearlystageinchronickidneydisease(PavikIetal.NephrolDialTransplant.2013Feb;28(2):352-9).Sincechronickidneydiseasefrequentlyoccurssecondarytoothermedicalconditions,α-KlothoisreceivingincreasingattentionasaMarkeroftheoccurrenceofchronickidneydiseaseinprimarydiseasessuchastype2diabetes(LeeEYetalPLoSOne.2014Aug1;9(8):e102984),wherebythesamplematerialshouldbenoted(seeimagebelow).