TheFGF19subfamilycomposedofFGF15/19,FGF21andFGF23bindstheFGFreceptorsco-joinedbyα-orβ-Klothoanditischaracterizedasafactorgroupwhichhashormonalfunctions.Thenovelsystemconsistedofα/βKlothoandFGF19subfamilyregulatesintegrallymetabolismofminerals,lipids,energyandaminoacids.Thisnovelregulatingsysteminvolvesimportanthomeostaticmechanismsinthebodysuchasbileacidandcholesterolmetabolismintheliver(throughFGF19),energyandglycolipidsmetabolism(throughFGF21)andphosphate,calciumandvitaminDmetabolisminkidney(throughFGF23)infastingstate.
FGF21issecretedintheliveranditisrespons
IBLeforglucoseuptakeof
ADIpocytes.FGF21bindstoareceptorunitconsistingofFGFRandβ-Klotho.IthasbeenshownthattreatinganimalswithFGF21leadstoincreasedenergyexpenditure,fatutilizationandlipidexcretionmeaningadecreaseofglucoseandtriglyceridelevelsinblood.
FGF21levelsinbloodcorrelatewithmanydiseaseslikegestationaldiabetesmellitus,mitochondrialdysfunctioninHIVinfection,friedreichataxia,coronaryarterydisease,carotidatherosclerosis,non-alcoholicfattyliverdisease,rheumatoidarthritis,diabeticnephropathy,type2diabetes,dyslipidemia,obesityandmetabolicsyndrome.
ThiskitmeasuresFGF21levelsinserum,EDTAplasmaandcellculturesupernatants.
Separatecontrolsetavailableonrequest
DistributedbyIBLInternational
ForconcretedatapleaseconsulttheInstructionforUseinthedownloadboxontherightside.