IntercellularAdhesionMolecule-1(ICAM-1)isamemberoftheimmunoglobulinsupergenefamilyandfunctionsasaligandfortheLymphocyteFunction-AssociatedAntigen-1(LFA-1),analpha-beta-complexthatisamemberoftheleukocyteintegrinfamilyofcell-cellandcell-matrixreceptors.ThisfamilyconsistsoftheleukocyteadhesionglycoproteinsLFA-1whichmediateslymphocyteadhesion,Mac-1whichmediatesgranulocyteadhesionandp150,95.ICAM-1isasingle-chainglycoproteinwithapolypeptidecorethatcanbeexpressedonnon-hematopoieticcellsofmanylineagessuchasvascularendothelialcells,thymicepithelialcells,otherepithelialcellsandfibroblastsandonhematopoieticcellssuchastissuemacrophages,mitogen-stimulatedT-lymphoblasts,germinalcenterB-cellsanddendriticcellsintonsils,lymphnodesandPeyer"spatches.ICAM-1isinduc
IBLeonfibroblastsandendothelialcellsbyinflammatorymediatorssuchasIL-1,TNFandIFN-gammawithinfewhoursandiscorrelatedtotheinfiltrationoflymphocytesintoinflammatorylesions.ICAM-1seemstobetheinitial
Markerofinflammatoryreactionsandisexpressedpriorto,andtoagreaterextentthanisHLA-DR.TheroleofICAM-1asadiseasemarkerhasbeendemonstratedforanumberofdifferentindicationsandpathologicalsituations.
Synonyms:Intercellularadhesionmolecule1,CD54antigen
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