Inhibinsareheterodimericpolypeptidehormones.Theyselectivelysuppressthesecretionofpituitaryfolliclestimulatinghormone(FSH)andalsohavelocalparacrineactionsonthegonads.Thefullyprocessedformoftheinhibinmoleculehasamolecularweightofapproximately32-36kDandconsistsofthetwodistinctchains(aandß),linkedbydisulfidebridges.Highermolecularweightforms,withprecursorformsofthea-subunit,alsooccurinfollicularfluidandserum.Inaddition,freea-subunitforms,unassociatedwithaß-subunit,andlackinginhibinbioactivity,arealsopresent.InhibinBconsistsofana-subunitandaßB-subunit.InhibinBisproducedbythesertolicellsofthetestisinthemaleandthegranulosacellsoftheovaryinthefemale.ItsprimaryroleappearstobeintheregulationofgametogenesisvianegativefeedbackontheproductionofFSH.SeveralpublishedreportsindicatetheutilityofmeasurementofInhibinBasanendocrine
Markerformonitoringthemaleandfemalegonadalfunction.TheInhibinBGenIIELISAusesthehighlycharacterizedpairofantibodiesthatspecificallyrecognizeonlythefunctionaldimericinhibinmoleculeanddoesnotmeasurethefreea-subunitformspresentin
BIOLOGicalfluids.Thecurrentassaydoesnotrequiresamplepre-treatmentstepwithhydrogenperoxidetooxidizetwomethioninesintheepitopetothesulfoxideforfullimmunoreactivity
Please,notethatStandardsandControlscanbeorderedseparatelyfrom
IBLundertheCatalogueNumberDS52026.
ForconcretedatapleaseconsulttheInstructionforUseinthedownloadboxontherightside.