ThisHighSensitivityELISAenablestheanalysisofTNF-alphainlowconcentrationsfromserum,plasma,orcellculturesamples.TheHighSensitivityELISAKitsofferaccuratequantificationbelowconventionalELISAlimits.
CD40belongstotheTNFreceptorsuperfamilyandisabiochemical
Markerfortheidentificationofactivatedplateletsofpatientswithcardiovasculardiseases(anginapectoris,infarction,strokeetc.)
AkeyroleofCD40/CD40ligandinteractionsinimmuneactivation,particularlyinT-celldependentBcellresponsesisanticipated.CD40LigandisexpressedonthesurfaceofactivatedCD4+Tcells,basophils,andmastcells.BindingofCD40Ltoitsreceptor,CD40,onthesurfaceofBcellsstimulatesB-cellproliferation,adhesionanddifferentiation.AsolubleisoformofCD40Lhasbeenshowntoexistinthecirculation.Thissolublemoleculeisahomotrimerofa18kDaproteinexhibitingfullactivityinBcellproliferationanddifferentiationassays,isabletorescueBcellsfromapoptosisandbindssolubleCD40.
CD40LisdiscussedinrelationtoapotentialroleinsupportingBcelltumorsandithasbeendiscoveredthatthemoleculardefectintheX-linkedHyper-IgM-SyndromeistargetedtotheCD40Lgene,itisfunctionalinvolvedinBcellhybridomasandchroniclymphocyticleukemiaaswellasseveralautoimmunediseases.
Synonyms:CD40Ligand;TNFligandsuperfamilymember5;TNFrelatedactivationprotein;TcellantigenGp39;CD154antigen;hyperIgMsyndrome
ForconcretedatapleaseconsulttheInstructionforUseinthedownloadboxontherightside.